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| Bisindolylmaleimide I ： ウィキペディア英語版 |
BIM-1
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BIM-1 and the related compounds BIM-2, BIM-3, and BIM-8 are bisindolylmaleimide-based protein kinase C (PKC) inhibitors. These inhibitors also inhibit PDK1 explaining the higher inhibitory potential of LY33331 compared to the other BIM compounds a bisindolylmaleimide inhibitor toward PDK1.
==Function==
The protein kinase C inhibitor bis(indolyl)maleimide inhibitor BIM1〔 is clearly seen in the structure of PKCiota (residue 574-turn motif), need to be phosphorylated towards a PKCbeta-specific inhibitor site-directed mutagenesis of the compound for its full activation and co-crystallized as an asymmetric pair which is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) are downstream characteristics of PKCs and PKB/AKT.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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